천연물로부터 알코올 탈수소효소 저해제 검색

• 영문명: Screening of Alcohol Dehydrogenase Inhibitors from Natural Products
• 발행기관: 대한약학회
• 저자명: 이현주(Hyun Joo Lee) 이강만(Kang Man Lee)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 481~486쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

Excessive or long term ingestion of alcohol may cause hepatitis, cirrhosis, hepatic tumor and so on. Aldehyde and active form of free oxygen that are metabolites of alcohol in liver are the cause of liver cell damage. The main system of alcohol metabolism is composed of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and cytochrome P450. In connection with in vivo alcohol metabolism, more than one hundred natural products were screened for inhibition or activation of alcohol dehydrogenase. As a results, we found significant inhibition (IC50) of ADH by methanolic extracts of Puerariae Radix (61.2mcg/ml), Glycyrrhizae Radix (105.0mcg/ml), Cinnamomi Ramulus (7.0mcg/ml), Rhei Rhizoma (36.7mcg/ml), Mori Cortex Radicis (106.2mcg/ml), Chrysanthemi Flos (112.2mcg/ml), Erycibes Caulis (36.7mcg/ml) and Scutellariae Radix (122.5mcg/ml).

키워드

Alcohol dehydrogenase (ADH) inhibitor natural products.