잔나비걸상버섯 수용성물질의 항인플루엔자바이러스 작용과 인터페론과의 병용효과

• 영문명: Anti-influenza Virus Activity of Water Soluble Substance from Elfvingia applanata Alone and in Combinations with Interferons
• 발행기관: 대한약학회
• 저자명: 정선식(Sun Sik Jeong) 어성국(Seong Kug Eo) 김영소(Young So Kim) 한성순(Seong Sun Han)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 469~473쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

EA. the water soluble substance, was prepared from the carpophores of Elfvingia applanata(Pers.) Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A. EA showed a concentration-dependent reduction in the plaque formation of Flu A with 50% effective concentration (EC50) of 1.50mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.

키워드

Combination index (CI) Elfvingia applanata influenza A virus (Flu A) plaque reduction assay.