Elfvingia applanata 수용성 물질의 항엔세파로미오카디티스 바이러스작용과 인터페론과의 병용효과

• 영문명: Anti-encephalomyocarditis Virus Activity of Water Soluble Substance from Elfvingia applanata Alone and in Combinations with Interferons
• 발행기관: 대한약학회
• 저자명: 김준희(Jun Hee Kim) 어성국(Seong Kug Eo) 김영소(Young So Kim) 한성순(Seong Sun Han)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 464~468쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

In order to find less toxic antiviral agents from basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-encephalomyocarditis (EMC) virus activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of EMC virus. EA exhibited a concentration-dependent reduction in the plaque formation of EMC virus with 50% effective concentration (ES50) of 2.12mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha showed potent synergism with CI values of 0.40~0.60 for 50%, 70% and 90% effective levels, but that with IFN gamma showed antagonism with CI values of 2.16~2.83.

키워드

Combination index (CI) Elfvingia applanata plaque reduction assay EMC virus.