HepG2 2.2.15 세포주를 이용한 가자, 지유, 복분자, 대황의 B형 간염바이러스 증식 억제 효과

• 영문명: Inhibitory Effects of Terminalia chebula, Sanguisorba officinalis, Rubus coreanus and Rheum palmatum on Hepatitis B Virus Replication in HepG2 2.2.15 Cells
• 발행기관: 대한약학회
• 저자명: 김태균(Tae Gyun Kim) 박민수(Min Su Park) 한형미(Hyung Mee Han) 강석연(Seog Youn Kang) 정기경(Ki Kyung Jung) 류항묵(Hang Mook Rheu) 김승희(Seung Hee Kim)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 458~463쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

This study was undertaken to test for antiviral activity of the aqueous extracts prepared from 4 medicinal plants of Korea (Terminalia chebula, Sanguisorba officinalia, Rubus coreanus, Rheum palmatum). Aqueous extracts were assayed for the inhibition of hepatitis B virus (HBV) replication by measurement of HBV DAN and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 64 to 128mcg/ml and inhibited the production of HBsAg dose-dependently. Among the 4 tested plants, Terminalia chebula exhibits the most prominent anti-HBV activities. Our findings suggest that these 4 medicinal plants may have potential to develop as specific anti-HBV drugs in the future.

키워드

Anti-hepatitis B virus HepG2 2.2.15 cell Terminalia chebula Sanguisorba officinalis Rubus coreanus Rheum palmatum.