Glycyl Norfloxacin 유도체의 합성과 항균작용

• 영문명: Synthesis and Antimicrobial Activity of Glycyl Norfloxacin Derivatives
• 발행기관: 대한약학회
• 저자명: 이현수(Hyun Soo Lee) 임채욱(Chaeuk Im) 임철부(Chul Bu Yim)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 442~446쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

The synthesis and antimicrobial activity of N-substituted glycyl derivatives of Norfloxacin were described. Norfloxacin was treated with chloroacetyl chloride to yield chloroacetyl norfloxacin(1). This compounds was treated with alkylamines to obtain quinolone carboxylic acids(2-6), which were reacted with pivaloyloxymethyl chloride to get pivaloyloxymethyl quinolone carboxylates(7-11). Free carboxylic quinolones(2-6) showed little stronger activities to their pivaloyloxymethyl esters(7-11). In quinolone analogues, longer alkyl chain compounds showed stronger activities than shorter one.

키워드

Norfloxacin antibacterial agent glycyl derivative.