수종의 천연물이 모노아민 옥시다제 활성에 미치는 영향

• 영문명: Effects of Herbal Medicines on Monoamine Oxiclase Activity (II)
• 발행기관: 대한약학회
• 저자명: 김영호(Young Ho Kim) 이상선(Sang Seon Lee) 배기환(Ki Hwan Bae) 김학성(Hack Seang Kim) 이명구(Myung Koo Lee)
• 간행물 정보: 『약학회지』제42권 제6호 (1998년), 634~638쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.12.31

영문 초록

The effects of MeOH extracts from 88 herbal medicines on monoamine oxidase (MAO) acitivity were investigated. MAO was purified from mouse brain and its activity was determined by fluorospectrophotometer using kynuramine as a substrate. The Km and Vmax values (n=4) of MAO were 78.2+/-4.0mcM and 0.65+/-0.05nmol/min/mg protein,respectively. Four MeOH extracts from Melilotus sauvelolens, Eupatorium lindleyanum Bupleurum longiradiatum and Sorbaria sirbiforia showed a strong inhibitory effect with less than 100mcg/ml in their IC50 values on MAO activity. Six MeOH extracts including Agastache rugosa showed a mild inhibitory effect with 100-200mcg/ml in their IC50 values. Twenty-two MeOH extracts including Melandryum seoulense exhibited a week inhibition of MAO activity with 200-300mcg/ml in their IC50 values.

키워드

Melilotus suaveolens Eupatorium lindleyanum Bupleurum longiradiatum Sorbaria sirbifolia Monoamine oxidase Mouse brain Kynuramine.