간장독성에서 니트릭 옥시드의 양면적 효과

• 영문명: Biphasic Effects of Nitric Oxide in Liver Toxicity
• 발행기관: 대한약학회
• 저자명: 박창원(Chang Won Park) 조대현(Dae Hyun Cho) 홍성렬(Sung Youl Hong) 한정환(Jeung Whan Han) 이향우(Hyang Woo Lee)
• 간행물 정보: 『약학회지』제42권 제6호 (1998년), 598~606쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.12.31

영문 초록

The liver expresses a considerable amount of nitric oxide (NO) upon induction with cytokines or/and endotoxin. The NO synthesized by inducible NO synthase (NOS) of the liver seems to play a role in various hepatic physiological processes. Here we investigate the effects of NO on acetaminophen (AA)-induced liver injury. The treatment of S-nitros-N-acetyl penicillamine (SNAP, exogenous NO donor) at the dose of 0.1mM decreased AA-induced hepatotoxicity suggesting the possibility of NO to play a role in protection from the hepatotoxicity induced by AA. On the other hand, the excessive NO produced by NO donor (SNAP: 0.5, 2.5, 6.25mM) has been shown to cause a concentration dependent hepatotoxicity, and such damages was decreased by Superoxide and increased by superoxide dismutase, indicating that the hepatotoxicity induced by excessive NO depends on balancing between NO and superoxide. Taken together, the results indicate that NO has biphasic effects on hepatotoxicity.

키워드

Nitric oxide superoxide hepatotoxicity acetaminophen.