글리실레틴산이 생쥐에 이식된 L1210 세포의 세포사에 미치는 영향

• 영문명: Effect of Glycyrrhetinic acid on the Cell Death of Transplanted-Ll2lO cells in Mice
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun) 권 진(Jin Kwon) 염정열(Jung Yul Yum) 오찬호(Chan Ho Oh)
• 간행물 정보: 『약학회지』제42권 제6호 (1998년), 583~588쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.12.31

영문 초록

These experiments were investigated effects of the cell death of glycyrrhetinic acid (GA) on transplanted-L1210 cells in BALB/c mice. The GA suppressed the proliferation of L1210 cells in vivo and in vitro system. The administration of GA induced apoptosis of transplanted-L1210 cells via the reduction of mitochondrial transmembrane potential in mice. The GA enhanced the production of nitric oxidation in peritoneal macrophages obtained from L1210 cells-transplanted mice. The apoptosis of L1210 cells were induced by co-culture of the macrophages obtained from GA administered mice and L1210 cells in vitro, and was partly inhibited by the treatment of L-NMMA. These results suggest that GA induces the cytotoxicity and the apoptosis of transplanted-L1210 cells via the production of nitric oxide in peritoneal macrophages.

키워드

Glycyrrhetinic acid apoptosis mitochondrial transmembrane potential macrophage nitric oxide cytotoxicity.