청피에 함유된 복강 마크로파지의 탐식작용 억제 성분

• 영문명: A Suppressive Component on Phagocytosis of Murine Peritoneal Macrophage in Aurantii immaturi pericarpium
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun) 김대근(Dae Keun Kim) 소준노(June No So) 지옥표(Ok Pyo Zee)
• 간행물 정보: 『약학회지』제42권 제6호 (1998년), 567~571쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.12.31

영문 초록

The phagoeytic activity of murine peritoneal macrophage, was determined by lucigenin chemiluminescence and engulfment of fluorescein-conjugated E. coli particle. The activity-guided fractionation upon the methylenechloride fraction of Aurantii immaturi pericarpium led to the isolation of a flavonoid, isosinensetin, as a suppressive component of phagocytosis. Isosinensetin suppressed the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and enhanced the production of nitric oxide in murine peritoneal macrophage.

키워드

Aurantii immaturi pericarpiumum Phagocytosis Macrophage Chemiluminescence Isosinensetin FITC-conjugated E. coli.