Bacillus sp. B-6가 생산하는 acyl CoA 합성 효소 억제 물질의 분리 및 구조 결정

• 영문명: Isolation and Structure Elucidation of Acyl CoA Synthetase Inhibitor from Bacilus sp. B-6
• 발행기관: 대한약학회
• 저자명: 김경자(Kyoung Ja Kim) 김태경(Tae Kyong Kim)
• 간행물 정보: 『약학회지』제42권 제6호 (1998년), 552~557쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.12.31

영문 초록

Acyl CoA synthetase inhibitor, was purified from the culture broth of a Bacillus sp. B-6, which had been isolated from soil, by chloroform extract, silica gel column chromatography and preparative TLC. The purified acyl CoA synthetase inhibitor showed higher Antifungal activity against C. al-bicans (MIC: 8mcg/ml). Though the analysis of UV spectrum, melting point, IR spectrum, Mass-spectrum, 1H-NMR and 13C-NMR spectrum, the inhibitor could be identified as phenazine-l-carboxylic acid.

키워드

Acyl CoA synthetase inhibitor Bacillus sp. B-6 Antifungal activity Phenazine-l-carboxylic acid.