근적외선 분광분석법을 이용한 타우린의 정량 분석

• 영문명: Quantitative Analysis of Taurine Using Near Infrared Spectrometry (NIRS)
• 발행기관: 대한약학회
• 저자명: 조창희(Chang Hee Cho) 김효진(Hyo Jin Kim) 맹대영(Dae Young Meang) 서상훈(Sang Hun Seo) 조정환(Jung Hwan Cho)
• 간행물 정보: 『약학회지』제42권 제6호 (1998년), 545~551쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.12.31

영문 초록

Near Infrared transmittance Spectroscopy (NIRS) was used to evaluate and quantify the pharmaceutical active compounds. In the paper, taurine (2-Aminoethanesulfonic acid) was quantitatively analyzed in commercial pharmaceutical preparations. For calibration a central composite factorial design was used to determine concentrations of ingredients in reference samples. For the quantitative analysis of taurine, the most suitable data analysis method includes the calculation of second derivatives and a partial least squares regression (PLSR) model. By NIR spectrometry, combined with PLSR, the taurine concentration was successfully predicted with a relatrve standard error of prediction (SEP) lower than 1.04%.

키워드

Near Infrared transmittance spectroscopy Taurine Central composite factorial design Partial least squares method.