활성화한 RAW 264.7 세포주에서 8-epi-xanthatin의 Nitric Oxide 생성저해

• 영문명: Inhibition of Nitric Oxide Synthesis by 8-epi-xanthatin in Activated RAW 264.7 Cells
• 발행기관: 대한약학회
• 저자명: 이화진(Hwa Jin Lee) 정연수(Yeon Su Jeong) 류시용(Shi Yong Ryu) 류재하(Jae Ha Ryu)
• 간행물 정보: 『약학회지』제42권 제5호 (1998년), 540~543쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.10.31

영문 초록

The nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase is known to be responsible for the vasodilation and hypotension observed in septic shock. We have found that 8-epi-xanthatin from Xanthium strumarium L. inhibited the production of NO in LPS-activated RAW 264.7 cells (IC50 value was 1.5 mcM). This activity was resulted from the suppressing of inducible nitric oxide synthase enzyme expression.

키워드

8-epi-xanthatin Xanthium strumarium L nitric oxide sesquiterpene inhibitor inducible nitric oxide synthase.