6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

• 영문명: The Evaluation of Antifungal Activities and Safeties of 6-(3,4-Dichlorophenyl)amino-7-chloro-5,8-quinolinedione
• 발행기관: 대한약학회
• 저자명: 윤여표(Yeo pyo Yun) 김동현(Dong Hyun Kim) 이병무(Byung Mu Lee) 허문영(Moon Young Heo) 정해문(Hae Moon Chung) 강혜영(Hye Young Kang) 최정아(Jung Ah Choi) 김도희(Do Hee Kim) 유충규(Chung Kyu Ryu)
• 간행물 정보: 『약학회지』제42권 제5호 (1998년), 527~533쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.10.31

영문 초록

6-(3,4-Dichlorophenyl)amino-7-chloro-5,8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. CK50 had ED50 0.22 +/- 0.01mg/kg. Ketoconazole as a positive control had ED50 6.00 +/- 1.70mg/kg. Intraperitoneally administered RCK50 at the ED50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD50 values were over 2,850mg/kg in ICR mice.

키워드

6-(3,4-dichlorophenyl)amino-7-chloro-5.8-quinolinedione, antifungal activity chromosomal aberration test Ames test micronucleus assay acute toxicity.