니트릭옥사이드의 합성 억제제인 NG-니트로-L-아르기닌의 신장작용

• 영문명: Renal Action of NG-Nitro-L-Arginine, Nitric Oxide Synthase Inhibitor, in Dog and Rabbit
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 유강준(Kang Jun Yu) 황명성(Myung Sung Hwang)
• 간행물 정보: 『약학회지』제42권 제5호 (1998년), 519~526쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.10.31

영문 초록

This study was performed in order to investigate the effect of renal function of NG-nitro-L-arginine (L-NOARG), inhibitor of nitric oxide (NO) synthase, in dog and rabbit. L-NOARG, when given intravenously in dogs, exhibited the decrease in urine flow (vol), renal plasma flow (RPF), osmolar clearance (Cosm) and amounts of sodium and potassium excreted in urine(ENa, EK). These renal functions of L-NOARG showed the same aspect in rabbit, too. L-NOARG, when administered into a renal artery, showed the same pattern as was obtained when given intravenously in both experimental and control kidney in dog. L-NOARG administered into the carotid artery showed the decrease in Vol, RPF, ENa, in a low doses that did not show any effect when given intravenously. Above results suggest that L-NOARG produces antidiuretic action in dog and rabbit, and these antidiuretic actions may be mediated by central action.

키워드

NG一nitro-L-arginine inhibitor of nitric oxide(NO) synthase antidiuretic action dog.