적출관류 간에서 대황, 마황 및 황금이 7-에톡시쿠마린의 대사에 미치는 영향

• 영문명: Effects of Rhei Rhizoma, Ephedrae Herba and Scutellariae Radix on the Metabolism of 7-Ethoxycoumarin in Isolated Rat Liver
• 발행기관: 대한약학회
• 저자명: 최기환(Ki Hwan Choi) 김순선(Soon Sun Kim) 박윤주(Youn Joo Park) 정혜주(Hye Joo Chung) 안미령(Mee Ryung Ahn) 서수경(Soo Kyung Suh) 신윤용(Yhun Yhong Sheen) 김동섭(Dong Sup Kim) 장영섭(Young Sup Chang)
• 간행물 정보: 『약학회지』제42권 제4호 (1998년), 422~430쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.08.31

영문 초록

In order to study the effects of Rhei rhizoma, Ephedrae herba and Scutellariae radix on hepatic metabolism, we examined the pretreatment effect of those on the metabolism of 7-ethoxycoumarin (EC). Water extracts (1g/kg) of Rhei rhizoma, Ephedrae herba and Scutellariae radix were administered orally to rats for 7 days, respectively. Livers were then isolated and perfused with 100mcM EC for 2 hours. The metabolites of EC, 7-hydroxycoumarin, sulfate conjugate and glucuronide conjugate were measured in the perfusates. The amount of glucuronide conjugates was decreased in Rhei rhizoma pretreated rats (p<0.01), however. 7-hydroxycoumarin was increased in Ephedrae herba pretxeated rats (p

목차

키워드

Rhei rhizoma Ephedrae herba Scutellariae radix hepatotoxicity metabolism isolated rat liver perfusion 7-ethoxy coumarin.

참고문헌