다년생 도라지의 항암 및 면역활성

• 영문명: Antitumor and Immunomodulatory Activities of the P. grandiflorum Cultivated for More Than 20 Years
• 발행기관: 대한약학회
• 저자명: 김영섭(Y. S. Kim) 이병의(B. E. Lee) 김근재(K. J. Kim) 이연태(Y. T. Lee) 조규봉(K. B. Cho) 정영철(Y. C. Chung)
• 간행물 정보: 『약학회지』제42권 제4호 (1998년), 382~387쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.08.31

영문 초록

Platycodon radix is a dried root of Platycodon grandiflorum (P. grandiflorum) A. DC, a perennial grown on the hills and fields in Korea and Japan, or cultivated in various districts. Recently, P. grandiflorum (Changkil) has been successfully cultivated for more than 20 years and generally has been employed as folk remedy for adult diseases such as hyperlipidemia, hypertension and diabetes. We investigated various biological activities of the extracts from Changkil. When treated in vitro with B16-F1 mouse melanoma cell lines, it showed 100% laminin-binding inhibitory activities at the concentration over 0.125mg/ml. In in vivo test it showed 61.5% reduction of the solid tumor weight transplanted in mice and exhibited anticancer activity of 128% ILS against Sarcoma-180 ascites. It also increased the ratio of positive cells of natural killer cells in lymphocytic composition against Sarcoma-18O ascites and solid tumor transplanted in ICR mice when tests were carried out by FACScan method.

키워드

P. grandiflorum (Changkil) laminin ascites tumor solid tumor natural killer cell.