목단피로부터 멜라닌 생성 억제성분의 분리

• 영문명: Isolation of Inhibitory Components on Tyrosinase Activity from the Bark of Paeonia moutan
• 발행기관: 대한약학회
• 저자명: 이승호(Seung Ho Lee) 박지수(Ji Soo Park) 김소영(So Young Kim) 김진준(Jin Joon Kim) 정시련(See Ryun Chung)
• 간행물 정보: 『약학회지』제42권 제4호 (1998년), 353~358쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.08.31

영문 초록

The MeOH extract of the bark of Paeonia moutan showed potent inhibitory effect on the mushroom tyrosinase activity in vitro. The activity-guided fractionation of the MeOH extract resulted in the isolation of three active compounds. The chemical structures of these compounds were elucidated by chemical and spectroscopic evidence as catechin, 1,2,3,6-tetra-O-galloyl-beta-D-glucose and 1,2,3,4,6-penta-0-galloyl-beta-D-glucose, respectively. Among them, the inhibitory activity by 1,2,3,6-tetra-galloyl-beta-D-glucose on mushroom tyrosinase was more potent (IC50=3.5mcM) than that of kojic acid (IC50=8.7mcM),but catechin enhanced the mushroom tyrosinase activity 50% in the concentration of 34.5M.

키워드

Paeonia moutan catechin galloyl glucose tyrosinase melanin polymer skin-whitening agent cosmetics.