펜틸렌테트라졸 투여 흰쥐에서의 천마의 항경련 작용기전

• 영문명: The Mechanism of Anticonvulsive Effect of the Rhizoma of Gastrodia Elata in Pentylenetetrazole Treated Rats
• 발행기관: 대한약학회
• 저자명: 허근(Keun Huh) 김진숙(Jin Sook Kim) 권태협(Tae Hyub Kwon) 김정애(Jeoung Ae Kim) 용철순(Chul Soon Yong) 하정희(Jeoung Hee Ha) 이동웅(Dong Ung Lee)
• 간행물 정보: 『약학회지』제42권 제4호 (1998년), 330~335쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.08.31

영문 초록

Gastrodia elata (GE) is a oriental medicinal herb which has been used traditionally for the treatment of various brain diseases including convulsion and epilepsy. In order to examine the mechanism of anticonvulsive effect, we treated the methanol extract of GE (500mg/kg, P.0) to the pentylenetetrazole (PTZ)-induced convulsive rats. Methanol extracts of GE significantly inhibited (35%) the convulsion state as well as the level of lipid peroxidation (25%) in the brain. The ether fraction of methanol extracts among the others effectively ibhibited in vitro lipid peroxidation dose dependently (5.OX10-6 - 2.OX1O-5g/ml). The scavenging effect on hydroxy radicals was found in all the fractions of ether, butanol, and dichloromethane. These results suggest that the anticonvulsive effect of GE is possibly due to the antioxidative effects of the active components in GE.

키워드

Gastrodia elata anticonvulsant antioxidant oxygen radical scavenging.