천연물로부터 항암면역증강물질 탐색연구

• 영문명: Screening of Antineoplastic Immunomodulator from Herbal Medicines
• 발행기관: 대한약학회
• 저자명: 송지영(Jie Young Song) 양현옥(Hyun Ok Yang) 표석능(Suhk Neung Pyo) 박신영(Sin Young Park) 김기환(Ki Hwan Kim) 손은화(Eun Hwa Son) 강남성(Nam Sung Kang) 윤연숙(Yeon Sook Yun)
• 간행물 정보: 『약학회지』제42권 제1호 (1998년), 132~139쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.01.31

영문 초록

Currently, cancer is the primary cause of death and 50% of cancer patients are incurable by surgery, radiotherapy and chemotherapy. Therefore, immunotherpy is interested as the fourth remedy. Biological response modifier (BRM), such as organometallic compounds, glycoproteins, polysaccharides and other natural products. Is the one which can enhance the immune response against cancer cell. To develop new BRM from natural sources, we investigated 63 species Korean traditional medicines by observing the mitogenic activity to splenocytes, generation of activated killer cells and activation of macrophages. Finally, we selected 9 species including Angelicae gigantis Radix, Mori Cortex Radicis, Arisaematis Tuber, Salviae Radix, Cnidii Rhizoma, Ligusti Fructus, Pasoraliae Semen, Loranthi Ramulus, Ginseng Radix. Bioassay-guided fractionation and purification is undergoing.

키워드

Plant extract antitum or immunostimulator mitogenic activity LAK cell macrophage.