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• 영문명: Measurements of Extracellular Excitatory Amino Acid Neurotransmitter Levels in Corpus Striatum of Toluene Inhaled Rat by Microdialysis
• 발행기관: 대한약학회
• 저자명: 백승경(Seung Kyung Baeck) 김해규(Hae Kyu Kim) 김철민(Cheol Min Kim)
• 간행물 정보: 『약학회지』제42권 제1호 (1998년), 95~100쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.01.31

영문 초록

Male Sprague-Dawley rats were exposed to the toluene at 3,000+/-200ppm via inhalation for two hours (single inhalation group), three weeks by two hours per day, six days per week (repeated inhalation group). We examined the level of excitatory amino acids of the extracellular neurotransmitter within the corpus striatum of rats by using in vivo microdialysis. Aspartate (Asp) and glutamate (Glu) of excitatory amino acid neurotransmitters were generally decreased in the inhalation groups compared with the control group, and more significantly decreased in the repeated inhalation group than in the single inhalation group except that Asp was increased from 60 min after the beginning of the inhalation to 30 min after the termination.

키워드

Toluene inhalation aspartate glutamate neurotransmitter.