Propionibacterium acnes에 대한 천연물의 항균효과 검색

• 영문명: Screening of the Antibacterial Activity of Natural Products against Propionibacterium acnes
• 발행기관: 대한약학회
• 저자명: 최승만(Seung Man Choi) 김민주(Min Joo Kim) 최영호(Young Ho Choi) 안호정(Ho Jung Ahn) 윤여표(Yeo Pyo Yun)
• 간행물 정보: 『약학회지』제42권 제1호 (1998년), 89~94쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.01.31

영문 초록

Propionibacterium acnes is the pharmacological target site of antiacne drugs. We have examined the antiacne activity of ninety seven natural products which have been used as Korean traditional medicines in various skin disorders. The antibacterial activity of extracts from the natural products were evaluated against P. acnes ATCC 9616 by disc method. Twelve natural products showed the potent antibacterial activity against P. acnes, and were, selected for the minimal inhibitory concentration(MC) against P. acnes. MICs of nine extracts were below 0.3% (w/v) and Sophora flavescens showed the most potent activity with a MIC of less than 0.008%(w/v) against P. acnes. Thus, the results suggest that nine natural products including S. flavescens can be developed as sources of promising potent antiacne agents.

키워드

Propionibacterium acnes antibacterial activity natural products Sophora flavescens.