3-(치환) 테트라조일메칠세파로스포린의 합성과 생리활성

• 영문명: Synthesis and Biological Activity of 3-(Substituted) Tetrazolylmethyl Cephalosporins
• 발행기관: 대한약학회
• 저자명: 고옥현(Ok Hyun Ko) 김영수(Young Soo Kim) 고봉석(Bong Suk Ko) 이재영(Jae Young Lee) 하재천(Jai Chun Ha) 방희재(Hee Jae Bang) 유진철(Jin Cheol Yoo) 강형룡(Hyung Ryong Kang)
• 간행물 정보: 『약학회지』제42권 제1호 (1998년), 12~24쪽, 전체 13쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.01.31

영문 초록

For the development of new cephalosporin antibiotics with aminothiazolcarboxymethylethoxyimino moiety on the C-7 position and tetrazolymethyl moiety on the C-3 position of cephem ring, 70-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[5-(substituted)tetrazol-2-yl]methyl-3-cephem-4-carboxylic acids(28-35) were synthesized. These compounds were tested for antimicrobial activity in vitro against Gram(+) and Gram(-) bacteria. They showed remarkable antibacterial activity against Escherichia coli AB 1157, Escherichia coli AB 0111, Escherichia coli BE 1186, Micrococcus luteus ATCC 9341, Salmonella typhimurium TV 119, Salmonella typhimurium SL 1102, Staphylococcus aureus IFO 12732, Staphylococcus aureus R-209, but these compounds were not active against Pseudomonas aeruginosa N-10.

키워드

Formylation ACLE tetrazole HOBT-DCC method Vilsmeyer reagent sillylation deformylation hydrolysis antibacterial activity.