흰쥐 조직에서의 카드뮴 결합 고분자량 단백질의 유도

• 영문명: Induction of Cd-biding High Molecular Weight Protein in Rat Tissues
• 발행기관: 대한약학회
• 저자명: 천기정(Ki Jung Chun) 김봉희(Bong Hee Kim)
• 간행물 정보: 『약학회지』제41권 제3호 (1997년), 352~358쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.06.30

영문 초록

The study was carried out on the biochemical characters of Cd-BP(I) after isolation and purification of the protein from the liver of rat injected intraperitoneally with Cd. A continued study has been doing whether Cd-BP(I) could be induced by Cd or by other metals such as Zn and Cu. Antisera were made against the Cd-BP(I) from NewZealand white rabbits. Carried out were gamma-globulin purification, then Ouchterlony test adn gel immunodiffusion test. Cd-BP(I) was also found in normal tissues of rat. It was induced up to a considerable level by Cd, whose induced level was higher than that of Cu or Zn treatment. The level of induction by Cu or Zn pretreatment plus Cd treatment was lower than that by simple treatment of Cu or Zn. Such a result was presumably related to the Cd toxicity.

키워드

Cd-binding high molecular weight protein Ouchterlony test gel immunodiffusion test induced level Cd toxicity.