세파로틴 나트륨의 결정형이 용출과 안정성에 미치는 영향

• 영문명: Effects of Crystal Modification of Cephalothin Sodium on Dissolution and Stability
• 발행기관: 대한약학회
• 저자명: 손영택(Young Taek Sohn) 박선희(Sun Hee Park)
• 간행물 정보: 『약학회지』제41권 제3호 (1997년), 321~327쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.06.30

영문 초록

Investigation of polymorphism has become a requirement in the pharmaceutical industry because the physical properties and bioavailabilities of crystalline drugs depend on their polymorphic form. Five polymorphic modifications and one pseudopolymorphic modification of ecphalothin sodium were prepared by recrystallization, and characterized by UV spectrophotometer, DSC, TGA and X-ray crystallography. The solubilities of all modifications were examined by the disslution test. Form 2 and 1 showed higher solubilities than any other crystal forms. The modifications were also investigated for their stability after storage of 2 months at 100%, 76%, 52% and 0% humidity.