항암제 안티네오플라스톤 A10의 동족체합성 및 항암 활성

• 영문명: Synthesis and Antitumor Activity of Antineoplaston A10 Analogs as potential Antineoplastic Agents
• 발행기관: 대한약학회
• 저자명: 최보길(Bo Gil Choi) 서희경(Hee Kyoung Seo) 김옥영(Ok Young Kim) 정병호(Bung Ho Chung) 오인준(In Jun Oh) 조원제(Won Jea Cho) 천승훈(Seung Hoon Cheon) 박민수(Min Soo Park) 최상운(Sang Un Choi) 이정옥(Chong Ock Lee)
• 간행물 정보: 『약학회지』제41권 제3호 (1997년), 283~293쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.06.30

영문 초록

Some analogs and their Mannich bases of Antineoplaston A10 (A10) were synthesized. Chemical yield for the 2-(or 3-)thienyl, benzol, and phenylpropionyl analogs were high but 1-naphthyl analog was synthesized in low yield. the Mannich bases formation of these analogs with morpholine went verywell compared to other bases. 1-Naphthyl, 4-nitrobenzoyl, and phenylpropionyl analogs of A10 showed weak in vitro activity but the other A10 analogs showed weaker or no activity at 10-1000mcg/ml. But their Mannich bases containing A10analogs showed good in vitro activity compared to simple A10 analogs.

키워드

Antineoplastic peptides Antineoplaston A10 analog 3-amino-2.6-piperidinedione Mannich base Antitumor agent.