새로운 카바페넴계 항생물질인 DWP20418의 In vitro 항균작용

• 영문명: In vitro Antibacterial Activity of DWP20418, a New Carbapenem Antibiotic
• 발행기관: 대한약학회
• 저자명: 김지연(Ji Yeon Kim) 최문정(Moon Jung Choi) 박남준(Nam Joon Park) 임성수(Seong Soo Yim) 변영석(Young Seok Byun) 유영효(Young Hyo Yu) 박명환(Myung Hwan Park)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 233~240쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

The in vitro antibacterial activity of DWP20418 (1R, 5S, 6S)-6-[1-(R)-Hydroxyethyl)-l-methyl-2-[(2S,4S)-2-(piperazinylcarbonyl)-1-(R)-hydroxyethyl)pyrrolidine-4-thio]carbapen-2-em-3-carboxylic acid), a new carbapenem antibiotic, was compared with those of imipenem (IPM) and meropenem (MEPM). DWP20418 was comparable or slightly more superior to MEPM against gram-positive bacteria, and it showed more potent activity to IPM against gram-negative bacteria. DWP20418 was particularly active against MRSA, and its MIC90 of methicillin-susceptible S. aureus, low methicillin-resistant S. aureus and high methicillin-resistant S. aureus were 0.391, 25 and 50 micro g/ml, respectively. With a view of MIC90, DWP20418 was comparable than the other carbapenems against P. aeruginosa and E. coli isolates. The activity of DWP20418 was not affected in the presence of Mg2+, Ca2+ or horse serum. But inoculum size and alterations in pH of medium affected its antibacterial activity. DWP20418 showed rapidly bactericidal activity within 1h, and regrowth was not observed even incubation of 24hrs at the concentrations near the MIC.

키워드

DWP20418 MIC Inoculum size effect Metal ion effect pH effect Serum effect Killing curve.