7-데아자하이포크산틴과 7-데아자아데닌 유도체의 합성

• 영문명: Synthesis of 7-Deazahypoxanthine and 7-Deazaadenine Derivatives
• 발행기관: 대한약학회
• 저자명: 신관석(Kwan Seog Sin) 김남호(Nam Ho Kim) 이주헌(Joo Heon Lee) 성선영(Sun Young Sung) Peter Pachaly
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 181~186쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

A series of 7-deazahypoxanthine and 7-deazaadenine derivatives[6,7.8.9.10,13] as purine antagonists was prepared. The pyrrolidine-5-one derivatives[4,11] were treated vith (C2H5)3OBF4 to give 3-aryl-5-ethoxy-2H-3,4-dihydropyrrole[5,12], which were converted to 7-aryl-7,8-dihydro-7(9H)-deazahy-poxanthine[6,7,8,9,10] and 7-phenyl-2-methyl-7,8- dihydro-7(9H)-deazaadenine[13].

키워드

7-deazahypoxanthine 7-deazaadenine purine antagonist 7-ary1-7.8-dihy dro-7(9H)-deazahypoxanthine7-phenyl-2-methyl-7.8-dihydro-7(9H)-deazaadenine.