Leptospermum Scoparium 수증기 추출물인 마누카 기름의 항균효과

• 영문명: Antimicrobial Activities of a Steam distillate of Leptospermum Scoparium
• 발행기관: 대한약학회
• 저자명: 이계주(Gye Ju Rhee) 정경수(Kyeong Soo Chung) 김은희(Eun Hee Kim) 서현주(Hyun Joo Suh) 홍남두(Nam Doo Hong)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 132~138쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

The antimicrobial activity of Manuka oil, a steam distillate from Leptospermum scoparium, was investigated, and it''s MIC against ten kinds of microorganisms was determined. MICs against bacteria and fungi were measured by means of both two-fold dliution method and agar plate two-fold dilution method, respectively. MICs of Manuka oil against Staphylococcus aureus KCTC 1916 and Micrococcus luteus KCTC 1915, gram-positive microrganisms, were identical as 3.05 mcg/ml, while it''s antibacterial activity against gram-negative microrganisms such as Pseudomonas aeruginosa KCTC 2513, Escherichia coli KCFC 1682, Klebsiella pneunioniae KCTC 2001 or Proteus vulgaris KCTC 2433 was negligible(MIC: > or = 1000 mcg/ml), suggesting a high susceptibility of gram-positive bacteria to Manuka oil. In addition, MIC against Aspergillus niger KCTC 6077 was 24 mcg/ml. and that against the other fungi, Tricophyton mentagrophytes KCTC 1374 and Candida albicans KCTC 1940 was > or + 1000 mcg/ml. When Manuka oil ointment was used in combination with other drugs. i.e.. gentamycin sulfate, chlotrimazol and hydrocortisone acetate, and diphenhydramine HCl and hydrocortisone acetate. it''s antibacterial activity against Staphylococcus aureus KCTC 1916 was higher than Manuka oil ointment or other drugs alone. In conclusion, Manuka oil possesses a selective antibacterial activity against Staphylococcus aureus KCTC 1916, and can be used as a potent antibacterial agent against it.

키워드

Manuka oil MIC Staphylococcus aureus Micrococcus luteus.