빌로바라이드가 글루타메이트에 의한 신경독성에 미치는 영향

• 영문명: Bilobalide Attenuates Glutamate-Induced Neurotoxicity in Primary Cultures of Rat Cortical Cells
• 발행기관: 대한약학회
• 저자명: 김소라(So Ra Kim) 장영표(Young Pyo Jang) 성상현(Sang Hyun Sung) 이흠숙(Heum Sook Lee) 문애리(A Ree Moon) 김영중(Young Choong Kim)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 111~116쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

The neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells could be attenuated by sesquiterpene constituent of Ginkgo biloba leaves, bilobalide. At the concentration of 100 nM, Bilobalide elevated the combined levels of reduced/oxidized glutathione in rat cortical cells exposed to 100mcM glutamate. Furthermore, bilobalide promoted a reduction in superoxide dismutase activity in glutamate-treated cells. Finally, bilobalide markedly inhibited the production of malondialdehyde. a measure of lipid peroxidation, in glutamate-treated rat cortical cells.

키워드

glutamate primary cultures of rat cortical cells bilobalide superoxide dismutase glutathione malondialdehyde.