영지버석(Ganoderma lucidum) 생장점으로부터 분리한 단백다당류의 면역활성

• 영문명: Immunoactivities of the Protein-polysaccharides of the Tips of the Growing Carpophores of Ganoderma lucidum
• 발행기관: 대한약학회
• 저자명: 정경수(Kyeong Soo Chung) 김상범(Sang Bum Kim) 정수현(Soo Hyun Chung)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 105~110쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

Two protein-polysaccharide fractions, GLA and GLB, respectively, were prepared from the pileus of the fully grown carpophores and the tips of the growing carpophores of Ganoderma lucidum. At a dose of 100mg/kg/day ip, GLA and GLB inhibited the growth of sarcoma 180 solid tumor in ICR mice by 56.3% and 81.8%, respectively. In a flow cytometric (FCM) analysis, GLA and GLB enhanced the formation of lymphoblasts of BALB/c, splenic leukocytes at a concentration of 100 mcg/ml, by 38.3% and 61, 3%, respectively. When ip injected into ICR mice, GLB exerted anti-leukopenic effect against cyclophospamide (75mg/kg, ip) in that the leukocyte counts of the peripheral blood of the normal and the cyclophosphamide-treated mice. respectively. was (11.1 +/- 3.8) x 103 and (4.0 +/- 1.8) x 103, while the GLB-cyclophosphamide treated mice showed a leukocyte count of (10.8 +/- 5.1) x 103 CELLS/mcl. These results suggest that GLB is a promising candidate for an effective, cancer immunotherapeutic agent.

키워드

Ganoderma lucidum GLA GLB flow cytometry lymphoblast-formation antitumor polysaccharide immunomodulator antileukopenic.