반고형제제의 유동특성에 관한 연구 (제2보) : 바셀린의 온도의존성 유동거동

• 영문명: Studies on the Flow Properties of Semi-Solid Dosage Forms (II) : Temperature-Dependent Flow Behavior of Vaseline
• 발행기관: 대한약학회
• 저자명: 김정화(Jeong Hwa Kim) 송기원(Ki Won Song) 장갑식(Gap Shik Chang) 이장우(Jang Oo Lee) 이치호(Chi Ho Lee)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 38~47쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

Using a concentric cylinder type, rheometer. the steady shear flow properties of vaseline were measured over the temperature range of 20~70oC. In this paper, the shear rate and temperature dependencies of its flow behavior were investigated and the validity of some flow models was examined. In addition, the flow characteristics over a wide temperature range were quantitatively evaluated by calculating the various material parameters. Main findings obtained from this study can be summarized as follows: (1) At relatively lower temperature range, vaseline is a plastic fluid with a yield stress and its flow behavior shows shear-thinning characteristics. (2) As the temperature increases, the value of a yield stress and the degree of shear-thinning become smaller, consequently, the Newtonian flow behavior occurs at a lower shear rate range. (3) At temperature range lower than 45oC, the flow behavior shows much stronger temperature dependence, and a larger activation energy is needed for flow. (4) The Herschel-Bulkley model is the most effective one g3 to predict the flow behavior of vaseline having a yield stress. The validity of the Bingham and Casson models becomes more available with increasing temperature. The flow behavior of vaseline at temperature range higher than 45oC can be perfectly described by the Newton model.

키워드

Vaseline flow behavior plastic fluids yield stress shear-thinning characteristics activation energy Herschel-Bulkley model Bingham model Casson model Newton model.