수용성 약물인 세파클로를 함유하는 젤라틴 마이크로캅셀의 제조 및 약물 방출특성

• 영문명: Preparation of Cefaclor-containing Gelatin Microcapsules and Their Drug Release Characteristics
• 발행기관: 대한약학회
• 저자명: 조성완(Seong Wan Cho) 박종화(Jong Hwa Park) 박준상(Jun Sang Park) 장정수(Joung Soo Jang) 최영욱(Young Wook Choi)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 30~37쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

In order to formulate a controlled release system for oral drug delivery, the microcapsules were prepared in w/o emulsion containing cefaclor as a water-soluble model drug by the method of interfacial polycondensation. Gelatin wis selected as a suitable polymer for interfacial polycondensation. Gelatin solution containing drug was emulsified in an organic phase under mechanical stirring. After emulsification, terephthaloyl chloride was added as cross linking agent, followed by mechanical stirring, washing and drying. Physical characteristics of microcapsules were investigated by optical microscopy, scanning electron microscopy and particle size analysis. Mean particle sizes of gelatin microcapsules were, in the range, of about 20~50mcm. The microcapsules were in good apperance with spherical shapes before washing, but were destroyed partially after washing and drying, even though some microcapsules were still maintained in their shapes. Contents of cefaclor in the microcapsules were calculated by UV spectrophotometry after 3 days extraction with pH 4 carbonate buffer solution. The effects of cross linking time. pH. concentration of cross-linking agent, and temperature on drug release kinetics have been discussed extensively.

키워드

Cefaclor Interfacial Polycondensation Gelatin Microencapsulation Controlled Release ride Cross-linking Controlled Release.