반복적인 Betaine투여가 간독성 및 Cytochrome P-450 의존성 약물대사효소계 활성에 주는 영향

• 영문명: The Effect of Repeated Betaine Treatment on Hepatotoxicity and Cytochrome P-450 Dependent Drug Metabolizing Enzyme System
• 발행기관: 대한약학회
• 저자명: 김상겸(Sang Kyum Kim) 김영철(Young Chul Kim)
• 간행물 정보: 『약학회지』제40권 제4호 (1996년), 449~455쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.08.31

영문 초록

Betaine is one of the major water-soluble components in Lycii Fructus. In the present study the effect of repeated betaine treatment on the hepatotoxicity and the cytochrome P-450-dependent enzyme system was examined in adult female rats. Administrations of betaine (100 or 1,000mg/kg/day, ip) to rats repeatedly for 4 or 9 days did not evoke hepatotoxic response as determined by increases in glutamic pyruvic transaminase(GPT) and glutamic oxaloacetic transaminase(GOT) activities measured 24 hours following the final dose of betaine. The activities of aminopyrine N-demethylase, p-nitroanisole O-demethylase and p-nitrophenol hydroxylase as well as the contents of cytochrome P-450 were determined in hepatic microsomes of rats treated with betaine(1,000mg/kg/day, ip) for 4 or 9 days. Repeated treatment of rats with betaine for a period of 4 days induced a marginal decrease in the contents of cytochrome P-450, but did not influence the activities of p-nitrophenol hydroxylase, p-nitroanisole O-demethylase, or aminopyrine N-demethylase. Extension of the betaine treatment to 9 consecutive days failed to alter the parameters for hepatic drug metabolizing activity determined in the present study. Since repeated large doses of betaine were demonstrated to be tolerated by rats without showing any toxicity or changes in drug metabolizing enzyme activities in the liver, this compound appears to be relatively safe to animals upon long-term ingestion.

키워드

Betaine Hepatotoxicity Cytochrome P-450 Aminopyrine N-demethylase p-Nitroanisole Odemethylase p-Nitrophenol hydroxylase.