생쥐의 호흡기 감염에 대한 퀴놀론계 항생제 LB20304a의 치료 효과

• 영문명: In vivo Efficacy of LB20304a against Experimental Respiratory Tract Infection in Mice)
• 발행기관: 대한약학회
• 저자명: 안미정(Mi Jeong Ahn) 김무용(Mu Yong Kim) 백경숙(Kyoung Sook Paek) 김인철(In Chull Kim) 곽진환(Jin Hwan Kwak)
• 간행물 정보: 『약학회지』제40권 제4호 (1996년), 438~441쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.08.31

영문 초록

The therapeutic activity of LB20304a was examined on experimental respiratory tract infection (RTI) caused by Klebsiella pneumoniae DT-S in mice. A single oral dose of LB20304a (1.2mg/mouse) showed a rapid bacteriocidal activity in lung tissue at 4,7 and 24h after administration of drug. The in vivo activity of LB20304a was comparable to that of ciprofloxacin against K. pneumoniae infection, although in vitro MIC of LB20304a was four-fold higher than that of ciprofloxacin.

키워드

LB20304a Quinolone Respiratory Tract Infection(RTI) Klebsiella pneumoniae DT-S.