항코린에스테라제 활성에 대한 파파베린 및 디펜히드라민의 효과

• 영문명: Effect of Papaverine and Diphenhydramine on the Action of Cholinesterase Inhibitors
• 발행기관: 대한약학회
• 저자명: 박은희(Eun Hee Park) 금정혜(Jeong Hye Kum) 박수선(Soo Sun Park)
• 간행물 정보: 『약학회지』제35권 제5호 (1991년), 438~443쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.10.30

영문 초록

This study was designed to examine the effects of diphenhydramine and papaverine on the toxic manifestations of cholinesterase inhibitors. It was found that papaverine increase acetylcholinesterase activity in cerebral cortex of mice. Papaverine pretreatment tended to increase acetylcholinesterase activity against the actions of neostigmine and physostigmine. When diphenhydramine (20-30 mg/kg, s.c.) was treated 20 min before the administration of cholinesterase inhibitor, it significantly extended the onset latency in the signs of toxicosis which were characteristically produced by physostigmine (0.25-1.5 mg/kg, s.c.) or neostigmine (0.125-0.5 mg/kg, s.c.), and it also prevented lethality in all of the animals.

키워드

Diphenhydramine papaverine physostigmine neostigmine toxic manifestation acetylcholinesterase activity.