트립토판이 스트레스 받은 쥐 뇌의 세로토닌과 오피에이트 수용체 결합에 미치는 영향

• 영문명: Effect of Tryptophan on Serotonin and Opiate Receptor Binding in Stressed Rats
• 발행기관: 대한약학회
• 저자명: 김은미(Eun Mi Kim) 김해리(Harriet Kim)
• 간행물 정보: 『약학회지』제35권 제4호 (1991년), 326~331쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.08.30

영문 초록

Brain serotonin and its utilization was investigated on stressed rats after feeding high tryptophan diet for a month. High tryptophan fed rats displayed significantly higher level of serum tryptophan, brain tryptophan, serotonin (5-hydroxytryptamine; 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) than the control diet fed rats. When rats were treated with 3 hour immobilization (IMMB) stress, serotonin turnover was slightly increased, but not statistically significant, in control diet group rats. However in high tryptophan diet rats, 3 hr IMMB stress resulted in statistically significantly (p<0.05) decreased the serum tryptophan, brain tryptophan and 5-HT level. The concentration of 5-HIAA was significantly increased indicating accelerated utilization of the brain 5-HT of the high trp. fed rat. The utilization pattern of the serotonin was found to be similar among young and adult rats. Rats on a tryptophan enriched diet displayed higher coping ability to the stress as they exhibited smaller increment of corticosterone level. A possible involvement of opioid system was suggested in serotonin utilization by measuring total 3[H]-naloxone binding in brain.

키워드

Serotonin tryptophan 5-hydroxyindoleacetic acid opiate receptor.