중추 노르아드레날린성 신경계 및 황체호르몬 분비 촉진호르몬에 대한 테스토스테론의 영향

• 영문명: Effect of Testosterone on Central Noradrenergic Nervous System and LHRH
• 발행기관: 대한약학회
• 저자명: 고흥숙(Hong Sook Koh) 김경진(Kyung Jin Kim) 박종세(Jong Sei Park) 고광호(Kwang Ho Ko)
• 간행물 정보: 『약학회지』제35권 제4호 (1991년), 295~300쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.08.30

영문 초록

Relationship between noradrenergic nervous system activity and luteinizing hormone releasing hormone(LHRH) content mediated by testosterone in hypothalamus was tested. Three groups of adult male animals were prepared; (1) Intact; (2) Castration+Vehicle (Cast+V); (3) Castration+Testosterone (Cast+T). Silastic capsule containing vehicle or testosterone was implanted into neck region of animals two weeks following castration. Norepinephrine content, alpha-adrenergic receptor binding characteristics using H3-WB4101, and content of LHRH by LHRH RIA procedure were determined. Testosterone replacement to castrated male rats augmented the content of norepinephrine and LHRH. Testosterone replacement increased the alpha-adrenergic receptor density but did not change alpha-receptor affinity. The data from the present study suggest that increase in LHRH content by testosterone may be positively coupled to the activity of central noradrenergic nervous system.

키워드

Testosterone noradrenergic nervous system LHRH hypothalamus.