와송의 항돌연변이 효과

• 영문명: Antimutagenic Effect of Orostachys japonicus
• 발행기관: 대한약학회
• 저자명: 박희준(Hee Juhn Park) 문숙희(Suk Hee Moon) 박건영(Kun Young Park) 최재수(Jae Sue Choi) 정해영(Hae Young Chung) 양한석(Han Suk Young) 서석수(Suk Soo Suh)
• 간행물 정보: 『약학회지』제35권 제4호 (1991년), 253~257쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.08.30

영문 초록

The anti-mutagenic effect of Orostachys japonicus (0J) toward aflatoxin (AFB1) and N-methyl-N''-nitro-N-nitrosoguanidine (MNNG) in the Salmonella assay system was studied. The methanol extract of OJ inhibited the mutagenicity induced by AFBI about 97% when 5% of the extract added to the system. Butanol fraction from the methanol extract was the most effective against AFB1. However, other fractions of hexane, chloroform, and ethylacetate also showed considerable antimutagenic activity against AFB1. Several identified compounds from the fractions of OJ exhibited anti-mutagenic effect. beta-Sitosterol, astragalin and kaempferol-3-rhamnosyl-7-glucoside were selected from the compounds, and these compounds inhibited the mutagenicity dose-dependently. These 3 compounds also decreased the mutagenicity induced by MNNG. From these results, it is suggested that the major compounds such as triterpene, sterol and flavonoid in the OJ were responsible for the inhibition of the AFB1 and MNNG-induced mutagenicities.

키워드

Orostachys japonicus aflatoxin B1 MNNG anti-mutagenicity.