효모에서 발현된 유전자 재조합 인간 성장호르몬의 일반 약리작용

• 영문명: General Pharmacology of Recombinant Human Growth Hormone Expressed in Saccharomyces cerevisiae
• 발행기관: 대한약학회
• 저자명: 이은방(Eun Bang Lee) 신국현(Kuk Hyun Shin) 정명숙(Myung Sook Chung) 김운자(Oon Ja Kim) 윤기영(Ki Young Yoon) 김정근(Jung Keun Kim)
• 간행물 정보: 『약학회지』제34권 제6호 (1990년), 439~446쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.12.28

영문 초록

The general pharmacological actions of recombinant human growth hormone (rHGH) were investigated. It had hypothermic action but neither sedative nor analgesic action. No pharmacological effects were observed in isolated guinea pig ileum and tracheal muscle and rat fundus and uterus. Slight hypotensive action with no effect on respiration was revealed at a dose of 20 IU/kg i.v. of rHGH in rabbits. The rHGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration (80IU/kg), and produced a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.

키워드

Recombinant human growth hormone general pharmacological actions insulin-like action.