상백피의 Sanggenon C에 의한 Streptococcus mutans의 생육 및 균부착 저해효과

• 영문명: The inhibitory Effect of Sanggenon C from the Root-bark of Morus alba L. on the Growth and Cellular Adherence of Streptocccus mutans
• 발행기관: 대한약학회
• 저자명: 박원재(Won Jae Park) 이형재(Hyung Jae Lee) 양승각(Seung Gak Yang)
• 간행물 정보: 『약학회지』제34권 제6호 (1990년), 434~438쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.12.28

영문 초록

The methanolic extract of the root-bark of Morus alba L.(Mulberry tree) has the potent antibacterial activity against Streptococcus mutans. Its active component was identified to be sanggenon C. The active had stronger anti-bacterial activity than berberine, having minimum inhibitory concentration(MIC) of 25mcg/ml. Moreover, the inhibitory effect of this component on the cellular adherence of streptococcus mutans to glass surfaces also was more remarkable than that of berberine in the presence of glucosyltransferase(GTase) and sucrose in vitro. These results indicated that sanggenon C may play an important role in inhibiting plaque formation and caries incidence.

키워드

Strcptococcns mutans Monts alba L. sanggenon C antibacterial caries glucan.