수용액 중 Trimebutine maleate의 안정성

• 영문명: Studies on the Stability of Trimebutine maleate in Aqueous Solution
• 발행기관: 대한약학회
• 저자명: 박종현(Jong Hyen Park) 이계주(Gye Ju Rhee)
• 간행물 정보: 『약학회지』제34권 제6호 (1990년), 415~421쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.12.28

영문 초록

The effects of temperature, pH, light and concentration on the degradation of trimebutine maleate in aqueous solution were investigated on the basis of accelerated stability analysis, and the stabilization of the solution was attempted by addition of several additives. The decomposition of trimebutine maleate in solution followed first-order reaction the was not only accelerated by temperature elevation but also the lower the concentration the more speeded up the reaction. The decomposition mechanism of trimebutine could be confirmed by hydrolysis of ester bond in the structure. It was assumed trimebutine maleate is so photosensitive that the solution of the drug underwent accelerated decomposition under UV rays. What is more, the degradation of trimebutine solution was supposed to catalyzed by specific acid-base catalysis considered the pH dependence for the hydrolysis of ester, and the solution was most stable over the range of pH 2-2.8 in solution. The additives, citric acid, aspartic acid and glutamic acid, inhibited considerably the decomposition of the drug solution, and these additives might be used as stabilizers in trimebutine maleate solution.

키워드

Stability trimebutine maleate first-order reaction hydrolysis UV pH dependence