Flavonoids의 약리작용(II) -항염작용과 창상치유 억제작용과의 상관성-

• 영문명: Pharmacological Activities of Flavonoids(II) Relationships of Anti-inflammatory and Antigranulomatous Actions
• 발행기관: 대한약학회
• 저자명: 김창종(Chang Johng Kim) 서수경(Soo Kyung Su) 주재현(Jae Hyun Joo) 조승길(Seung Kil Cho)
• 간행물 정보: 『약학회지』제34권 제6호 (1990년), 407~414쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.12.28

영문 초록

The relationships of inhibitory activities of inflammation and wound healing of flavonoids were studied in vitro and in vivo. Generally flavonoids have not only significantly anti-inflammatory activity in carrageenin-induced paw edema and Freund''s complete adjuvant-induced arthritis, but also inhibitory activity of wound healing. The more inhibitory activities Of wound healing flavonoids have. the more they have the anti-inflammatory activities; apigenin > guercetin > flovone > rutin > hesperidin > naringin. Their inhibitory mechanism seems to be inhibition of the inflammatory cell infiltration and fibroblast proliferation, and so they decreased the granulomatous activity and tensile strength.

키워드

Flavonoids carrageenin-induced paw edema Freund’s complete adjuvant arthritis granulomatous action fibroblast growth tensile strength histology of wound healing.