5-Fluorouracil-지질 결합체 합성 및 in vitro 항암효과 평가

• 영문명: Syntheses of 5-Fluorouracil-Fat Conjugates and Evaluation of Their in vitro Cytotoxic Activity
• 발행기관: 대한약학회
• 저자명: 이희주(Hee Joo Lee) 장판섭(Pan Sup Chang) 김재완(Jae Wan Kim) 정기화(Ki Hwa Jung) 신순희(Soon Hee Shin) 신혜순(Hae Soon Shin) 정순복(Soon Bog Jung)
• 간행물 정보: 『약학회지』제34권 제6호 (1990년), 395~400쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.12.28

영문 초록

The FU-fat conjugates(4a-e) as a prodrug have been synthesized by condensing various fatty acids(1a-e) via isocyanates(2a-e) as carbamoyl group at N1-position of 5-fluorouracil and their structures characterized. Preliminary testing for their antitumor effect was carried out on leukemia L1210 cells in culture. Most of them(4a-d) like the parent FU exhibited less than 50% inhibition on grouth of the cultrued cells at the concentration of 1X10-7M. Only a dicarboxylic acid derivative, 4e, showed over 50% inhibition at the same level.

키워드

5-fluorouracil-fat conjugates.