일산화탄소가 뇌내 신경전달물질 및 그 합성효소에 미치는 영향

• 영문명: Effect of Carbon Monoxide on the Monoamine Neurotansmitter and Synthetic Enzyme in Rat Brains.
• 발행기관: 대한약학회
• 저자명: 윤재순(Jae Soon Yun)
• 간행물 정보: 『약학회지』제34권 제6호 (1990년), 384~394쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.12.28

영문 초록

We studied the effect of carbon monoxide(CO)-induced bypoxia on monoamine neurotransmitter and their syntheitc enzyme in rat brain. When the rats were acute or chronic intoxicated at CO 5000 ppm for 30 minutes or 2000 ppm for 1 week each 3 hours, dopamine content increased significantly with decreasing of its turnover in striatum and norepinephrine content was diminished in hypothalamus. 5-hydroxytryptamine content was increased significantly and its turnover was decreased both in striatum and hypothalamus. Tyrosine hydroxylase activity was reduced in striatum. These results suggest that inhibition of TH activity in CO-induced hypoxia is owing to lack of oxygen supply threfore NE content is decreased. We suggest that increasing of dopamine and 5-hydroxytryptamine are due to reduction of its turnover.

키워드

CO intoxication norepinephrine dopamine DOPAC homovanillic acid 5-hydroxytryptamine hydroxyindoleacetic acid，tyrosine hydroxylase.