7 beta-Diphenyl Triazolyl Thioacetamidocephalosporin의 합성과 항균작용

• 영문명: Synthesis and Antimicrobial Activity of 7 beta-Diphenyl Triazolyl Thioacetamido Cephalosporin
• 발행기관: 대한약학회
• 저자명: 김영수(Young Soo Kim) 고옥현(Ok Hyun Ko) 강형룡(Hyung Ryong Kang)
• 간행물 정보: 『약학회지』제34권 제2호 (1990년), 117~121쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.04.28

영문 초록

7beta-[4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl]thioacetoamidocepharosporanic acid was synthesized by condensation of 7-Aminocephalosporanic acid (7-ACA) with [4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl] thioacetylchloride. This compound was tested for antimicrobial activity in vitro against nine species of microorganisms. It showed remarkable antibacterial activity against Bacillus subtilis, Micrococcus luteus, and Staphylococcus aureus.