1,4-Dihydropyridine의 Dialkylaminomethyl화 유도체의 합성

• 영문명: Dialkylaminomethylation of 1,4-Dihydropyridine
• 발행기관: 대한약학회
• 저자명: 서정진(Jung Jin Suh) 홍유화(You Hwa Hong)
• 간행물 정보: 『약학회지』제33권 제5호 (1989년), 280~284쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.10.28

영문 초록

When 2,6-Dimethyl-4-(3''-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester(3) was reacted with dimethyl methylene ammonium chloride (5a) and K2CO3 in DMF, 2,6-dimethyl-4-(3''-nitrophenyl)-5-(N,N-dimethylamino)methyl-1,4-dihydropyridine-3-carboxylic acid methyl ester (6a) was obtained in 41% yield. As the same procedure with compound (3) and the other dialkylaminomethylating reagents (5b, c, d, e), 2,6-dimethyl-4-(3''-nitrophenyl)-5-(N,N-diethylamino)methyl-1,4-dihydropyridine-3-carboxylic acid methylester(6b), 2,6-dimethyl-4-(3''-nitrophenyl)-5-(1''-pyrrolidinyl)methyl-1,4-dihydropyridine-3-carboxylic acid methyl ester (6c), 2,6-dimethyl-4-(3''-nitrophenyl)-5-(1''-piperidinyl)methyl-1,4-dihydropyridine-3-carboxylic acid methyl ester (6d) and 2,6-dimethyl-4-(3''-nitrophenyl)-5-(1''-morpholinyl)methyl-1,4-dihydropyridine-3-carboxylic acid methyl ester (6e) were obtained in 28%, 49%, 48% and 18% yield respectively.

키워드

2,6-Dimethyl-4-(3'-nitrophenyl)-l,4-dihydropyridine-3,5-dicarboxylic acid 3-monomethyl ester dialkyl methylene ammonium chloride,2,6-Dimethyl-4-(3'-nitrophenyl)-5-(N,N-dialkylamino) methyl-1,4-dihydropyridine-3-carboxylicacid methylester Dialkylaminomethylation