알파-아밀라제 저해제 생성 Streptomyces DMCJ-49의 동정과 저해제의 분리

• 영문명: Identification of Streptomyces DMCJ-49 Producing the alpha-Amylase Inhibitors and the Isolation of the Inhibitor
• 발행기관: 대한약학회
• 저자명: 정동직(Dong Jik Chung) 곽진환(Jin Hwan Kwak) 최응칠(Eung Chil Choi) 김병각(Byong Kak Kim)
• 간행물 정보: 『약학회지』제33권 제3호 (1989년), 175~182쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.06.25

영문 초록

To find alpha-amylase inhibitors produced by microorganisms from soil, a strain which had a strong inhibitory activity against bacterial alpha-amylase was isolated from the soil sample collected in Korea. The morphological and physiological characteristics of this strain on several media and its utilization of carbon sources showed that it was one of Streptomyces species according to the International Streptomyces Project method. The amylase inhibitor of this strain was purified by active carbon adsorption, silicagel column chromatography, SP-Sephadex C-25 column chromatography, adsorption on Amberlite XAD-2. The inhibitor was oligosaccharide which was composed of glucose. The inhibitor had inhibitory activity against other amylase such as salivary alpha-amylase, pancreatic alpha-amylase, fungal alpha-amylase and gluco-amylase.

키워드

α-amylase inhibitor Streptomyces oligosaccharide