Ibuprofen의 합성

• 영문명: Synthesis of Ibuprofen
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi)
• 간행물 정보: 『약학회지』제32권 제5호 (1988년), 340~342쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.08.29

영문 초록

New synthetic method for ibuprofen, which is a potent antiinflammatory agent, was described. Ethyl alpha-methylthio-p-isobutylphenylacetate was obtained from Friedel-Crafts reaction of isobutylbenzene with ethyl alpha-chloro-alpha-(methylthio)acetate in the presence of SnCl4. Ibuprofen was prepared in good yield by treatment of ethyl alpha-methylthio-p-isobutylphenylacetate with NaH and MeI, followed by desulfurization with zinc dust-acetic acid and hydrolysis of the resultant ethyl 2-methylthio-2-(4-isobutylphenyl)propionate.