고혈압 동물에서 혈압변동과 적혈구변형능의 상관성

• 영문명: Relationship between Blood Pressure Changes and Erythrocyte Deformability in Hypertensive Rats
• 발행기관: 대한약학회
• 저자명: 고광호(Kwang Ho Ko) 이명걸(Myung Gull Lee) 김낙두(Nak Doo Kim) 조윤성(Yun Sung Chough) 권석윤(Seok Yoon Kwon) 윤재순(Jae Soon Yun)
• 간행물 정보: 『약학회지』제31권 제5호 (1987년), 308~314쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.10.30

영문 초록

In cardiovascular disease the flow adaptation of erythrocytes can be affected by reduced shear stresses and metabolic influences on red cell fluidity as a consequence of tissue hypoxia. In addition there are indications that risk factors of cardiovascular diseases are able to decrease the intrinsic red cell deformability. Erythrocyte deformability was studied by the filtration technique of Reid et al. to investigate the relationship between blood pressure chances and erythrocyte deformability. In this experiment normotensive rats, spontaneously and DOCA-salt treated hypertensive rats were used. Erythrocyte deformability was significantly reduced by blood pressure elevation in hypertensive rats but was not fully recovered by normalization of blood pressure after antihypertensive drug treatment. Therefore other factors than blood pressure may be involved in erythrocyte deformability reduction during blood pressure elevation.