Lactobacillus sporogenes에 의한 혈중 Cholesterol의 저하

• 영문명: Lowering of Serum Cholesterol by Lactobacillus sporogenes
• 발행기관: 대한약학회
• 저자명: 석은경(Eun Kyung Seok) 김태한(Tae Han Kim) 이정치(Jung Chi Lee) 정필근(Pil Keun Chung) 이금기(Kum Ki Lee)
• 간행물 정보: 『약학회지』제31권 제5호 (1987년), 302~307쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.10.30

영문 초록

The increase in the serum cholesterol level of the rabbit fed a high cholesterol diet was prevented by the administration of a Lactobacillus sporogenes preparation, proportionally to the amount of the preparation. About 90% of the increase, in the serum cholesterol level was inhibited in the rabbits fed the preparation (2%) as feed additives. In vitro, L. sporogenes cultured in MRS broth containing PPLO serum fraction as a cholesterol source decreased the cholesterol concentration in the spent broth and increased the intracellular cholesterol concentration. The ability of L. sporogenes to accumulate cholesterol was enhanced by the presence of oxgall in the medium. These results suggest that L. sporogenes may directly assimilate the cholesterol in the gastrointestinal tracts and may prevent the increase of the serum cholesterol level.